Nanoparticle-Based Radiosensitization
نویسندگان
چکیده
منابع مشابه
Biological mechanisms of gold nanoparticle radiosensitization
There has been growing interest in the use of nanomaterials for a range of biomedical applications over the last number of years. In particular, gold nanoparticles (GNPs) possess a number of unique properties that make them ideal candidates as radiosensitizers on the basis of their strong photoelectric absorption coefficient and ease of synthesis. However, despite promising preclinical evidence...
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Radiosensitization using gold nanoparticles (AuNPs) has been shown to vary widely with cell line, irradiation energy, AuNP size, concentration and intracellular localization. We developed a Monte Carlo-based AuNP radiosensitization predictive model (ARP), which takes into account the detailed energy deposition at the nano-scale. This model was compared to experimental cell survival and macrosco...
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A rapid development of gadolinium-based nanoparticles is observed due to their attractive properties as MRI-positive contrast agents. Indeed, they display high relaxivity, adapted biodistribution and passive uptake in the tumor thanks to enhanced permeability and retention effect. In addition to these imaging properties, it has been recently shown that they can act as effective radiosensitizers...
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Gold nanoparticle (GNP) can be used as a radiation sensitizer in radiotherapy, and many Monte Carlo simulation studies have focused on this issue. A nanodosimetry biophysics Monte Carlo code NASIC was used in this work to study both the physical and biological radiosensitization effect of GNP in the cell environment under the irradiation of X-ray. GNP-cell models were built in the simulation wi...
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ژورنال
عنوان ژورنال: International Journal of Molecular Sciences
سال: 2020
ISSN: 1422-0067
DOI: 10.3390/ijms21082879